Qualitative Phytochemical Screening, Anti-inflammatory and Haematological Effects of Alkaloid Extract of Combretum dolichopetalum Leaves

Background: Inflammation has been implicated in a number of wounds and disease conditions, spurring the search for compounds with anti-inflammatory properties.

Aim: The study investigated the anti-inflammatory potentials and effect of alkaloid extract of Combretum dolichopetalum on haematological parameters of Wistar albino rats.

Methodology: Alkaloids in the leaves were extracted using 10% acetic acid as solvent. The anti-inflammatory potential was investigated using egg-albumin paw edema model, while the haematological effects of the extract was observed on plasma.

Results: Phytochemical screening showed the presence of alkaloids, saponins and tannins in moderate concentration. Alkaloid specific test showed the presence of six classes of alkaloids. Result for anti-inflammatory potentials showed a significant (p<0.05) reduction in paw size of extract treated group compared to negative control. The extract also stabilized haematological parameters compared to negative control.

Conclusion: In conclusion, the study confirms the use of the alkaloid extract of Combretum dolichopetalum leaves in pain management and inflammatory conditions.